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Fig. 1
Early phenotype of Dlx5/6-inactivated zebrafish and mouse.
(A-B) Phenotype of wild type (WT) and dlx5a/6a morphant zebrafish at 48 hpf (n>750 for each condition). (C-D) Phenotype of WT and Dlx5/6-/- mutant mice at E11.5 (n = 6 for each condition). Inactivation of Dlx5/6 in zebrafish and mouse leads to early defect of posterior axis development characterized by curly-shaped tail phenotype in both models (B, D, white arrowheads). In Dlx5/6-/- embryos, the caudal phenotype is associated with defect of brain formation (D, blue arrowhead). Scale bar in B for A-B 100 μm, for C-D 1000 μm.
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