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Fig. S4
a, Pravastatin and rosuvastatin interfere with heart looping. In addition, cardia bifida could be observed. In situ hybridization for cardiac myosin light chain 1 (cmlc2). Scale bar: 100 μm. *p=0.0165 (20 μM prava.), **p=0.0087 (50 μM prava), ****p<0.0001. Two-tailed Fisher’s exact tests (all compared to DMSO-treated controls). b, Pancreas placement is also randomized by treatment with other statins. **p=0.0023, ***p=0.0001, ****p<0.0001.Stacked bar graphs summarize data of 4 experiments with 123 (DMSO), 97 (20 μM pravastatin), 90 (50 μM pravastatin) and 91 (50 μM rosuvastatin) embryos.
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