ZFIN Image: Maerz et al., 2019, Fig. S2

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Figure Caption

Fig. S2

a, Zebrafish embryos were treated from tailbud stage until 48 hpf with mevastatin or rosuvastatin. b, Live images of embryos treated either with vehicle (1% DMSO in egg water, Control), 2 or 20 nM mevastatin and 50 μM rosuvastatin. Arrow indicates pericardiac oedema. Scale bar: 200 μm. c, The formation of pericardiac oedema upon statin treatment. * p=0.0187, ** p=0.0011. d, Heart rate decreases with statin treatment. **** p<0.0001. e, Meva- and rosuvastatin produce curved bodies. * p=0.0300, *** p=0.0003. f, Meva- and rosuvastatin treatment also results in otolith defects. * p=0.0309. Number of embryos given below graphs. Red line indicates median. c, e and f, number of experiments: 9 (DMSO), 5 (meva.) and 4 (rosu.) c-f, Kruskal-Wallis test with Dunn’s multiple comparison test. Statin vs. respective statin.

Acknowledgments

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