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Figure Caption
Fig. S1
lamtor4 is essential for CNS myelination.
(A) Analysis of mbp mRNA expression at 5 dpf by whole mount in situ hybridization. Compared to their wildtype siblings, lamtor4-/- mutants show reduced mbp expression in the CNS (white arrows), whereas mbp expression in the PNS is normal (black arrows). All panels show dorsal views, with anterior to the top. Genotypes were determined by PCR after imaging. Scale bar = 50 μm.
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Reprinted from Developmental Cell, 47, Meireles, A.M., Shen, K., Zoupi, L., Iyer, H., Bouchard, E.L., Williams, A., Talbot, W.S., The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex, 319-330.e5, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell