ZFIN Image: Peters et al., 2018, Fig. 5

Image

Figure Caption

Fig. 5

Gata1 binds distal and proximal promoter elements to regulate Hemogen expression in zebrafish. (A) Gata1 ChIP-sequencing showing enriched binding of Gata1 at CNE1 and CNE2 (C1 and C2, red lines) in the Hemogen promoter in adult zebrafish red blood cells (Yang et al., 2016). DNase-sequencing and ATAC-sequencing showing co-localization of the active chromatin regions (Yang et al., 2016). (B) Hemogen expression by WISH of wild-type (n=16/21) and (C) homozygous mutant (n=5/21) siblings (33 hpf) from in-crossed Gata1^+/− vlt^m651 mutants. Insets show βe1-globin expression in mutant (n=4/10) and wild-type (n=6/10) siblings. Scale bar: 250 µm (C).

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Acknowledgments

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