ZFIN Image: Oosterhof et al., 2018, Fig. 5

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Figure Caption

Fig. 5

Differential Gene Expression of csf1r-Deficient Microglia Shows Normal Microglia Differentiation

(A) Volcano plot showing expressional changes of the 300 most highly expressed microglia-specific genes in csf1ra^−/−;b^+/− mutant microglia (Oosterhof et al., 2017).

(B) Volcano plot showing the expressional changes in csf1ra^−/−;b^+/− mutant microglia of normally downregulated genes during differentiation (Matcovitch-Natan et al., 2016) and of genes normally expressed in other macrophages in the CNS (Bennett et al., 2016).

(C) Volcano plot showing the expression changes of non-microglia myeloid genes.

(D) Expression values of zebrafish microglia-specific genes.

(E) Expression values of downregulated microglia-specific genes.

(F) Expression values of upregulated microglia-specific genes.

(G) Representative images of microglia (5-month-old fish) in the ventral part of the optic tectum labeled with an antibody against L-plastin. Scale bar, 20 μm.

Figure Data

Expression / Labeling details

Acknowledgments

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