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Fig. 2
Compounds 2 and 8 ameliorate CE and jaw defects caused by loss of kmt2d. (a) Compounds 2 and 8, but not 28 (negative control), rescue CE defects of kmt2d morphants. (b) Alcian blue staining of jaw. Depletion of kmt2d leads to a change in jaw layout, reducing the distance between Meckel’s (MK) cartilage and ceratohyal (CH) cartilage (red double arrow). Treatment with compound 2 or 8, but not 28, ameliorates this defect in kmt2d morphants. (c) Quantitative measurement of the distance between MK and CH cartilages (n > 25). *p < 0.05; **p < 0.01; ***p < 0.001. Error bars show SEM (standard error of the mean).
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