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Fig. S3
cyp26c1 mutant embryos have ectopic egr2-expressing cells
(A-D): Expression of egr2 was analyzed in cyp26c1 mutant embryos. Ectopic egr2-expressing cells were observed in r2 and r4 (arrowheads), as seen in morphants (Fig.6B). That this phenotype occurs following inactivation of cyp26c1 alone suggests that RA levels in r2 and r4 are altered sufficiently to disrupt identity switching. Scale bar: 50 μm.
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Reprinted from Developmental Cell, 45, Addison, M., Xu, Q., Cayuso, J., Wilkinson, D.G., Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain, 606-620.e3, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell