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Fig. S8
rb1D7/D7 mutant cells in M-phase lack expression of the neuronal differentiation marker HuC/D. A, B High magnification image of phosphohistone-H3 positive nuclei (B, arrows) and HuC/D-positive cells in the tectum of a 5 dpf rb1D7/D7 mutant brain. No overlap is detected between cells expressing HuC/D (C, red) and phosphohistone-H3 (D, green, arrows, dashed outlines). The chromatin in the phosphohistone-H3 positive cells appears highly condensed (E, arrows), consistent with cells in prophase/prometaphase of the cell cycle.
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Full text @ Dis. Model. Mech.