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Fig. 2
Depdc5 knockdown larvae show an early hyperactive motor phenotype. (A) Locomotor activity heatmap illustrating spontaneous movement in 28 hpf larvae inside the chorion over a period of 1 min showing an increase in general movement in the Depdc5 knockdown (KD) larvae as compared to mismatch and noninjected controls. (B) Parameters of the same activity showing increased frequency and amplitude of movement in Depdc5 KD animals. C. Quantification of total activity showing a significant hyperactive phenotype in the Depdc5 KD. Both the coiling and twitching frequency were significantly increased as compared to controls.
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