ZFIN Image: Morrice et al., 2018, Fig. 2

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Figure Caption

Fig. 2

BPA exposure impairs NMJ integrity. (a) Representative images of α-bungarotoxin (post-synaptic terminal) and synpatotagmin 2 (pre-synaptic terminal) labeling in wild type embryos at 48 hpf exposed to BPA vehicle control, or control media. Inset magnifications are merged images of the pre- and post-synaptic terminals. SC, spinal cord. (b) Data are based on the integrity of the NMJ at 48 hpf in control, vehicle control and BPA exposed embryos as measured by Pearson’s R² co-localization coefficient between α-bungarotoxin and synaptotagmin 2. P = 0.02, N = 8–15 biological replicates; P = 0.006, N = 15 biological replicates; N = 5–6 technical replicates of motor neurons. P values were determined by Mann-Whitney U test.

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Acknowledgments

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