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Fig. S11
AG1478 blocks heart regeneration in WT hearts, but not in the dusp6 mutant hearts. (A-D) Sections of hearts at 20 dpa stained with AFOG to visualize the deposition of fibrotic tissue. AG1478 treated WT hearts (B) (n=6) show larger area of fibrotic tissue when compared to DMSO control treatments (A) (n=9). However, AG1478 did not result in suppressing heart regeneration in dusp6pt30a/pt30a mutants (D) (n=9), compared to DMSO (C) (n=9). (E) Graph showing the measurements of fibrotic tissue areas at 20 dpa. **p<0.01, *p<0.05; n.s.=not significant. One-way ANOVA. Scale bars, 100 μm.
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