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Fig. 5
Osteoclastic activity revealed by TRAP staining. TRAP activity (red staining, arrows) in the predecessor tooth in wt (A) and sp7 mutant (C) zebrafish, likely elicited by growth of a replacement tooth (asterisk in C). Inset in C shows magnification of TRAP activity involved in removal of the dentin (d). Note small size of the mutant teeth compared to the wt (A). TRAP activity (red staining, arrows) involved in remodelling of the ceratobranchial bone opposite a developing tooth (asterisk) is not different between wt (B) and mutant (D) fish. Scale bars = 50 µm.
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Reprinted from Developmental Biology, 435(2), Kague, E., Witten, P.E., Soenens, M., Campos, C.L., Lubiana, T., Fisher, S., Hammond, C., Brown, K.R., Passos-Bueno, M.R., Huysseune, A., Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth, 176-184, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.