ZFIN Image: Gou et al., 2018, Fig. 9

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Fig. 9

Roles foratoh1a-neurog1cross-repression but not Notch in sensory-neural segregation. (A, B) Expression of atoh1a at 30 hpf in a control (A) and hs:neurog1/+ (B) embryo following serial heat shock at 24 and 27 hpf, for 60 min at 39 °C. (C, D) Expression of neurog1 at 30 hpf in a control (C) and hs:atoh1a/+ (D) embryo following serial heat shock at 24 and 27 hpf, for 60 min at 39 °C. (E, F) Co-staining of atoh1a (red) and neurog1 (black) expression by two-color in situ hybridization in a control embryo (E) and a mib homozygote mutant (F) at 24 hpf. Otic vesicle borders are outlined in all images. The width of the utricular macula is marked by vertical lines. All images show dorsolateral views with anterior to the left.

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Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B., sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear, 73-83, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.