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Fig. 9
BIO does not prevent fibre hypertrophy in myodfh261 mutant. A. Larvae from an incross of myodfh261/+;Tg(Ola.Actb:Hsa.HRAS-EGFP)vu119 were sorted for GFP, treated with BIO or vehicle from between 2 and 3 dpf and imaged live at 4 dpf by confocal microscopy. Red outlines highlight typical fast fibres. Bar 50 µm. B,C. Quantification of mean fibre volume (B) and fibre number (C) from two replicate experiments was performed blind. Each larva was retrospectively sequence genotyped and the data pooled. Differences were tested by ANOVA with Bonferroni multiple comparison test.
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Reprinted from Developmental Biology, 431(2), Roy, S.D., Williams, V.C., Pipalia, T.G., Li, K., Hammond, C.L., Knappe, S., Knight, R.D., Hughes, S.M., Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration, 321-335, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.