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Fig. s1 Supplementary Figure 1. (A) Myocardial nuclei density, defined as number of myocardial nuclei per field to myocardial density, showing no difference in two groups at week 32 (p > 0.05). (B) Masson’s staining did not show any interstitial fibrosis in the two groups (n = 15 field, repeated five times); scale bar = 100μm. (C) Co-staining of PCNA (green), Mef2 (red) with DAPI (blue) on cryosections of adult zebrafish hearts, indicating no significant difference in PCNA staining between wild-type and treated group (n = 15 field, repeated five times); scale bar = 10μm；Arrows: PCNA+/Mef2+/DAPI+. (A) Bars represent mean ± standard error of the mean, n = number of fish examined.