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Fig. 6
IRF6 missense gene variants can rescue periderm rupture and restore normal craniofacial development.
(A-T) Craniofacial morphologies of maternal-null irf6 -/- embryos rescued by human IRF6 missense gene variant mRNA microinjections (100 pg/embryo) at 96 hpf stained with alcian blue. (A-D) Uninjected wild type control. (E-H) p.P12L. (I-L) p.P76L. (M-P) p.T100A. (Q-T) p.P222L. Scale bars = 150 μm, n = 3.
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