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Fig. S1
Metformin ameliorates dorsal axis curvature in pkd1a/b and pkd2 morphants. Zebrafish embryos were treated with metformin (10 mM) in supplemented E3 media between 4 and 48 hours post fertilisation (hpf). (A) Representative images showing the common body axis of a control embryo, and the mild and severe dorsal curvature phenotypes of pkd1a/b and pkd2 morphants at 48 hpf. (B) Comparative frequencies of the dorsal curvature phenotype in the pkd1a/b and pkd2 morphants with and without metformin treatment. Data represent two independent experiments. *P < 0.05, **P < 0.01. Scale bar, 200 µm.
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