|
Fig. S6
A morphological defect of blood vessels in mysterin morphants is not restored by fast muscle-specific expression of human mysterin.
(a) Visualization of the vascular structure in the fliEGFP transgenic line. Although three branches of the nasal ciliary artery (white arrows) drain into the inner optic circle (IOC; yellow arrows) in control animals, multiple aberrant vessels drain into the IOC (red arrows) in morphants. This phenotype is not restored by fast muscle-specific expression of human mysterin. (b) Guidance of trunk vessels is severely impaired by mysyerin-α knockdown (red arrows). This anomaly is not restored by fast muscle-specific expression of human mysterin. RFP shows fast muscle-specific Gal4 activity.