ZFIN Image: Sedykh et al., 2017, Fig. 1

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Fig. 1

Zebrafish Zic2 is required during retinal morphogenesis. A: normal retinal morphology. B: retina exhibiting mild coloboma (*). C: retina exhibiting severe coloboma with periocular hemorrhaging (**). D: normal retinal morphology. E: bilateral coloboma in a severely affected embryo (**). F: mild, unilateral coloboma in an affected embryo. G: Penetrance and expressivity of coloboma is increased in progeny that lack maternal zic2b, derived from zic2a^gbt133/+; zic2b^t104/zic2b^t104 parents, compared to those from double heterozygous (zic2a^gbt133/+; zic2b^t104/+) parents (see Table S1 for details). H, I: Both CRISPR- and TALEN-induced mutant alleles of zic2b are tightly associated with coloboma in MZ-zic2 embryos. Embryos in A-C are at 2–3 dpf, shown in lateral views, anterior to the left. Embryos in D-F are at 4 dpf, shown in anterior views, dorsal at the top.

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Acknowledgments

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Reprinted from Developmental Biology, 429(1), Sedykh, I., Yoon, B., Roberson, L., Moskvin, O., Dewey, C.N., Grinblat, Y., Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis, 92-104, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.