ZFIN Image: Xie et al., 2016, Fig. 3

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Fig. 3

In Gα₁₃-deficient embryos, the medial migration of endocardial precursors is affected by impaired endoderm convergence. Epifluorescence time-lapse experiments were performed on control (A-H) and gna13a/b MO-injected (A′-H′) Tg(fli: EGFP/sox17: memCherry) embryos (Supplementary movie 2). (A-H′) Snapshots from movies, showing the migration of endocardial precursors (green, arrowheads) and convergent movement of the endoderm (magenta) at the stages indicated. As the embryos are curved, only the lateral boundaries of the endodermal sheet were focused, the midline region was out of focus. Dorsoanterior views. White arrowheads: endocardial precursors that migrated to the midline briefly. (I) Endoderm width (magenta) plotted against distance between the two populations of endocardial cells (green) at the stages indicated. Data are mean±s.e.m. Scale bars: 100 µm.

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Acknowledgments

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Reprinted from Developmental Biology, 414, Xie, H., Ye, D., Sepich, D., Lin, F., S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence, 228-43, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.