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Fig. S4
nrg2a-/- hearts develop functional atrioventricular valves
(a-c) Maximum intensity z-projections (25 z-stacks, sagittal sections) of 120 hpf Tg(kdrl:NLSEGFP); nrg2a+/- AV canal showing that Nrg2a-mRFP is weakly expressed in the AV valve leaflets. (d-i) Mid-sagittal confocal images of hearts from Tg(kdrl:NLS-EGFP);nrg2a+/- incrosses at 80 (d-f) and 120 (g-i) hpf; arrows and arrowheads point to superior and inferior valve leaflets, respectively; V: ventricle, AV: atrioventricular canal, At: atrium; scale bars, 50 μm.
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Full text @ Nat. Commun.