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Fig. 8
osm-3/kif17mw405 cilia appear to form normally, although disc formation is delayed. A-C. TEM was performed on three wild-type and osm-3/kif17mw405 embryos at each of five timepoints during the early stages of OS morphogenesis between 50hpf and 60hpf. An average of 22±1 basal bodies were imaged for each sample and categorized into one of three ciliary states: no cilia (A), cilia without discs (B), or cilia with discs (C). Scale bar is 0.5 µm. While there does not appear to be a delay in initial ciliogenesis, disc morphogenesis specifically appears to be delayed in osm-3/kif17mw405 embryos.
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Reprinted from Developmental Biology, 425(2), Lewis, T.R., Kundinger, S.R., Pavlovich, A.L., Bostrom, J.R., Link, B.A., Besharse, J.C., Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms, 176-190, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.