ZFIN Image: Lei et al., 2017, Fig. 1

Image

Figure Caption

Fig. 1

The CNS and spinal cord undergo apoptosis and fail to differentiate in fn10a mutants. (A, A) An fn10a mutant (A) showing morphological defects in the brain and tail compared with a wild-type sibling (sib) embryo (A). (B, B’) TUNEL staining showing that the fn10a mutant (B) had severe apoptosis in the CNS and neural tube. (C–F, C’–F’) In situ staining for neural markers revealed that differentiated neuronal markers (D–D’, map2; E–E’, tuba; F–F’, pax2) but not a neural progenitor marker (C–C’, nestin) were affected in fn10a mutants (C–F) compared with those in their siblings (C–F). Scale bars, 200 μm. The number of embryos assayed was ≥13 for each panel.

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Acknowledgments

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