ZFIN Image: Anelli et al., 2017, Fig. 6

Image

Figure Caption

Fig. 6

Identification of a gene expression signature from adult zebrafish thyroid carcinomas conserved in human patients with thyroid cancer.

(A) Schematic diagram of the RNA-seq workflow from adult (12mpf) thyroid tissue. (B) Heat-map depicting the top differentially expressed genes in tg-BRAF^V600E-TOM thyroid tissue compared to tg-TOM thyroid tissue (Figure 6—source data 1). (C) GSEA hallmark gene sets significantly enriched in tg-BRAF^V600E-TOM. (D) Volcano plot depicting differentially expressed genes in tg-BRAF^V600E-TOM compared to tg-TOM thyroid tissue; a set of 58 genes (blue, FDR ≤ 1 × 10⁻⁶, FC ≤1.5, (Figure 6—source data 2) was defined as a signature of BRAF^V600E expression in thyroid carcinoma. (E) Kaplan-Meier analysis of disease free survival in 496 patients with papillary thyroid cancer stratified by median BRAF^V600E gene expression signature identified in (D).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife