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Fig. 5
Synergistic activities of chd and dkk1b mRNA induce the formation of a dorsal axis with a complete head structure in ichabod embryos. Phenotypic representation of (A) uninjected (63/63), (B and C) dkk1b mRNA-injected (48/64), (D and E) chd mRNA-injected (55/64), (F and G) chd and dkk1b mRNA-injected (47/58), and (H and I) β-catenin mRNA-injected ichabod embryos (48/62). (C, E, G, and I) Magnified images of the head region of B, D, F, and H. All embryos are shown at 24 hpf. Scale bars represent 100 µm. (J) Phenotypic classes obtained for each treatment.
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Reprinted from Developmental Biology, 424(2), Tanaka, S., Hosokawa, H., Weinberg, E.S., Maegawa, S., Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish, 189-197, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.