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Fig. S11
BMS-833923 treatment produces sustained inhibition of Hh/Smo signaling. Fins from ptch2:Kaede fish were amputated and subsequently injected with DMSO or 40 mg/kg BMS-833923 at 48 and 72 hpa. (A, E) At 96 hpa, Kaede protein was photoconverted on half of the fin and immediately imaged. Fish were monitored for expression of new Kaede protein at 6 dpa (B, F), 9 dpa (C-C', G-G'), and 18 dpa (D-D', H-H'). Scale bars: 500 μm.
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