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Fig. S5
MEK inhibitor treatment does not inhibit tumor growth in MYCN;GFP or MYCN;Gab2wt transgenic fish. Related to Figure 7
(A) EGFP-expressing tumors in MYCN;GFP (arrowhead) or MYCN;Gab2wt (arrow) transgenic fish treated with trametinib at days 1 or 15 of treatment. Scale bar, 1 mm.
(B) Changes in tumor volume in animals treated with trametinib on day 15 vs day 1, as measured by the size of EGFP positive tumor masses using Image J software. Mean values (horizontal bars) were compared by Welch t-test (two-tailed).
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