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Fig. 6
The effects of β-cyclodextrin included in compound K (CD-CK) and CK (compound K) with diazoxide (DZ) in alloxan-induced pancreatic islet-damaged zebrafish. (A) The size change in the pancreatic islets in each group. (B) Fluorescence intensity analysis in the pancreatic islets of the zebrafish. (C) Representative final pancreatic islet images of the normal (NOR), alloxan (AX), DZ, CK, CK with DZ, CD-CK, and CD-CK with DZ groups. Pancreatic islets are stained with 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose. The white arrow indicates the location of pancreatic islet. Scale bar = 100 μm. ##p < 0.01, ###p < 0.001 compared to normal. * p < 0.05, ** p < 0.01, *** p < 0.001 compared to alloxan. ++ p < 0.01.