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Fig. 4
The effects of 5μM compound K (CK) and β-cyclodextrin included in compound K (CD-CK) in alloxan-induced pancreatic islet-damaged zebrafish. (A) The size change in the pancreatic islets in each group. (B) Fluorescence intensity analysis in the pancreatic islets of zebrafish. (C) Representative final pancreatic islet images of the normal (NOR), alloxan (AX), β-cyclodextrin (β-CD), glimepiride (GLM), CK, and CD-CK groups. The pancreatic islets are stained with 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose. The white arrow indicates the location of pancreatic islet. Scale bar = 100 μm. #p < 0.05 and ###p < 0.001, compared to the normal group. * p < 0.05, ** p < 0.01, and *** p < 0.001, compared to the alloxan group.