ZFIN Image: Lu et al., 2017, Fig. 2

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Fig. 2

The LA1110 gene is required for cardiac progenitor formation. (A–J) Dorsal views of nkx2.5 (A and B), mef2ca (C and D) and myl7 (E–J) expression in wild type and LA1110 mutant embryos. In wild type embryos, expression of nkx2.5 (A) and mef2ca (C) are detected in the cardiac progenitors within the ALPM at the 10-somite stage. These cells then differentiate into myl7-expressing cardiomyocytes (E) by the 16-somite stage and migrate toward the midline and fuse to form a cardiac cone (G) which then grows into a linear heart tube by 26 hpf (I). In LA1110 mutant embryos, expression of nkx2.5 (B) and mef2ca (D) is strongly reduced. Even though the expression of myl7 is far lower (F), the myl7-expressing cardiomyocytes in LA1110 mutant embryos migrate to the midline and form the cardiac cone at the 20-somite stage (H) and the linear heart tube at 26 hpf (J).

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Acknowledgments

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Reprinted from Developmental Biology, 421(2), Lu, F., Langenbacher, A., Chen, J.N., Tbx20 drives cardiac progenitor formation and cardiomyocyte proliferation in zebrafish, 139-148, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.