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Fig. S7
Wnt expression and signaling in Nr5a2 mutants and morphants. A) wnt2 expression in the mesoderm region between the swim bladder and pancreas (arrows) is unaffected in nr5a2+/oz3 and nr5a2oz3/oz3 embryos relative to controls. B) qPCR for Wnt target genes in whole embryos reveals that alterations in Nr5a2 activity by antagonist Cpd3 from 50 - 72 hpf does not significantly impact Wnt pathway activity.
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Reprinted from Developmental Biology, 418(1), Nissim, S., Weeksb, O., Talbot, J.C., Hedgepeth, J.W., Wucherpfennig, J., Schatzman-Bone, S., Swinburne, I., Cortes, M., Alexa, K., Megason, S., North, T.E., Amacher, S.L., Goessling, W., Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development, 108-23, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.