ZFIN Image: Bhuiyan et al., 2016, Fig. 2

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Fig. 2

Neutrophils are indispensible for zebrafish survival from A. baumannii infection. (A) Phagocytosed A. baumannii (pHrodo-dextran stain, white arrow) is handled within acidic phagolysosomes within a neutrophilic vacuole at 50-min postinfection [Tg(mpx:GFP)^il14 embryos with green fluorescent neutrophils were used]. (Scale bar: 20 µm.) Survival of neutrophil-depleted embryos (csf3r MO) (B) or macrophage-depleted embryos (irf8 MO) (C) after bloodstream infection with A. baumannii. Comparison is made vs. A. baumannii-infected embryos injected with control morpholino (Ctrl MO; P < 0.001; n = 30 embryos, three biological replicates).

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA