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Fig. 6
Impaired Notch signaling alleviates the fbxw7 morphant phenotype in zebrafish.
Offspring resulting from an intercross of heterozyogous dll4j16e1 mutants were injected with fbxw7 ATG MO and the ISV morphology was analyzed at 32 hpf. The fraction of embryos showing normal ISV growth (light grey) was highest in a dll4 homozygous background. In contrast, fbxw7 silencing led to defective ISV growth (black) in almost all dll4 wild-type embryos. The ratio of ISV phenotypes within each genotype group was calculated (based on 3 independent experiments). Error bars reflect SEM. P value (*) is <0.05.
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