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Fig. 6
Inhibition of inflammation strongly decreases CM proliferation after cryoinjury. (a-c) Representative images of the hearts of cmlc2:DsRed-nuc fish (red) treated with 0.05% DMSO (a), 500 nM PLX3397 (b) or 5 µM flumethasone (c) labelled with the cell cycle marker MCM5 (green). The cryoinjured area is detected by the absence of cmlc2:DsRed-nuc (encircled with a dashed line). Arrows indicate double-positive cells. (d,e) Quantification of MCM5-positive CMs and non-CMs at 7 dpci. (n ≥ 4 hearts; ≥2 sections per heart; ***p < 0.001).
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