ZFIN Image: Mawdsley et al., 2004, Fig. 7

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Figure Caption

Fig. 7

Failure to form a lumen in the neural tube of Neogenin morphants. (a) Oblique transverse section through the telencephalon towards the ventral diencephalon stained with hematoxylin and eosin demonstrated that the diencephalic ventricle (v) was formed in the control by 24 hpf. (b) Equivalent section from a Neogenin morphant where no ventricle was formed. (c) The lumen (lu) of the rostral neural tube was apparent in control embryos at 24 hpf. (d) The lumen was absent in the rostral neural tube of morphants. Cells in the bilateral columns of neuroepithelium were fewer and poorly organized in Neogenin morphants (b and d) compared to those in control embryos (a and c). Some cells had delaminated from the neuroepithelium in the morphants and were ectopically positioned in the region where the lumen would normally have formed (b and d: arrows). ml, midline.

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Acknowledgments

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Reprinted from Developmental Biology, 269(1), Mawdsley, D.J., Cooper, H.M., Hogan, B.M., Cody, S.H., Lieschke, G.J., and Heath, J.K., The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish, 302-315, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.