Fig. 9 S1
Chemical inhibiton of PI3K, mTORC1 or NFkB rescues the epidermal malignancies, but not the pericardial edema of psoriasis mutants.
(a-h) Representative live images of psoriasis -/- embryos at 54 hpf, treated with the PI3K inhibitors Wortmannin (1 然; c,c′), PIK90 (5 然; d,d′) and LY 294002 (25 然; e,e′), the mTORC1 inhibitors Rapamycin (1.1 然; f,f′) and AZD8055 (30 然; g,g′), and the NFκB inhibitor Withaferin A (30 然; h, h′), as quantified in Figure 9e. Treatment with the different inhibitors of components of the PI3K-Akt-mTorC1-NFκB pathway do not rescue the pericardial edema (c- h, compare to wt (a) and non-treated mutant (b)), but do rescue the epidermal malignancies of mutant embryos (c′-h′, compare to wt (a′) and non-treated mutant (b′)). Scale bars: 500 痠 (a), 250 痠 (a′).