ZFIN Image: Hatzold et al., 2016, Fig. 10 S2

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Figure Caption

Fig. 10 S2

mmp9 knockdown alleviates epidermal invasiveness.

Examples of whole mount immunofluorescence of laminin (red) and type II collagen (green) of the tail fin of 58 hpf psoriasis-/- embryos (a,b) and psoriasis-/- ; mmp9 MO embryos (c,d)-, counterstained with DAPI (blue). Actinotrichia disassembly (a′-d′) and basement membrane disruption (a′′-b′′) observed below epidermal aggregates (arrows in a′′′-d′′′) are strongly reduced upon knockdown of mmp9. In total (5 embryos examined per condition), 5/22 medium-sized fin fold aggregates were associated with BM fragmentation in mmp9 MO-injected mutants, compared to 19/19 in un-injected mutant controls.

Acknowledgments

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