ZFIN Image: Chng et al., 2013, Fig. S1

Image

Figure Caption

Fig. S1

Homozygous ela^br21 and ela^br15 Mutants and ela overexpressing Fish Have Similar Phenotypes, related to Figure 3

(A) Wildtype larvae at 6 days post-fertilization.

(B) The 7 amino-acid in frame mutant ela^br21 allele causes identical phenotypes as the two frameshift mutants ela^br13 and ela^br15.

(C) The ela^br15 mutant fish are indistinguishable from the ela^br21 and ela^br15 alleles.

(D) Overexpression of 200 pg of zebrafish ela ORF mRNA causes heart dysgenesis (open arrows) and accumulation of erythrocytes in the ICM (red arrows), similar to ela null fish.

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Cell, 27(6), Chng, S.C., Ho, L., Tian, J., and Reversade, B., ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor, 672-680, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell