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Fig. 11
Hh signaling is required after Fgf signaling for postchordal neurocranial development. The expression of has2 is retained following either (A-A′) DMSO or (B-B′) cyclopamine treatment from 6 to 10 h post-fertilization (hpf). (C and D and F-H) DMSO- and cyclopamine-treated embryos from 6 to 10 hpf show expression of both sox9a and col2a1a at 24 hpf, however, (E and H) cyclopamine-treated embryos from 10 to 24 hpf show a loss of sox9a and col2a1a expression in the postchordal neurocranium at 24 hpf. Arrowheads denote the anterior limit of the notochord. scale bar=50 µm in A and 10 µm in A′.
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Reprinted from Developmental Biology, 415(2), McCarthy, N., Sidik, A., Bertrand, J.Y., Eberhart, J.K., An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull, 261-77, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.