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Fig. 10
A network of Fgf ligands regulates otic-epibranchial induction. A: Initial otic induction is mediated by Fgf3 and Fgf8 from the hindbrain (HB) and sub-otic mesoderm. B: During secondary otic recruitment, cells converging from more lateral regions initially encounter mesodermal Fgf10b followed by Fgf3. Newly recruited cells continue to join the otic placode through 12.5 hpf (Bhat and Riley, 2011). C: In a final phase, epibranchial fates are induced by a combination of mesodermal Fgf10b and Fgf3 and otic Fgf24. Cells in the facial placode are induced first, followed by cells in more posterior epibranchial tissue (Nechiporuk et al., 2007).