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Fig. 1
Generation of a zebrafish grk2 null mutation
A. Phylogenic tree showing the relationship of the various vertebrate Grk genes and the Drosophila gprk gene.
B. Schematic representation of the exon 1 nucleotide sequence of zebrafish grk2 gene targeted by the ZFN.
C. Schematic representation of the zebrafish Grk2 protein domains and the truncated peptide predicted to be encoded by the grk2i283 mutant allele.
D. Homozygous grk2i283 mutant at 4dpf compared to wild type (WT) sibling (N = 80). Arrows indicate the position of swim bladder. Scale bar, 1 mm.
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Full text @ EMBO Rep.