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Fig. S3
Misregulation of msxd in scales of sp7 mutants. A-D) In fish transgenic for Runx2:egfp and sp7:mch, GFP+ cells are confined to the distal tip of the scale (arrow in A), while mCh is expressed in those cells as well as more broadly along the scale (B). E, F) While in situ hybridization for msxd reveals little scale expression in WT fish (E), it shows dramatic upregulation in sp7 mutants (F), suggesting a role for Sp7 in regulating BMP signaling during scale growth.
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Reprinted from Developmental Biology, 413(2), Kague, E., Roy, P., Asselin, G., Hu, G., Stanley, A., Albertson, C., Simonet, J., Fisher, S., Osterix/sp7 limits cranial bone initiation sites and is required for formation of sutures, 160-72, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.