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Fig. S2
sp7 mutant skulls are phenotypically variable. A-E) Skulls of sp7 mutants at 8 wpf were fixed, stained with Alizarin red, and dissected for analysis. Phenotypic severity varies from a mildly affected skull (A) to almost completely unmineralized skull (E). Extra sutures are present in all fish (arrows in A-E), and patches of unmineralized bone are commonly observed (asterisks in B-D). F) in a senescent fish (>2.5 years), decreased mineralization is observed in flat bones (lighter coloration).
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Reprinted from Developmental Biology, 413(2), Kague, E., Roy, P., Asselin, G., Hu, G., Stanley, A., Albertson, C., Simonet, J., Fisher, S., Osterix/sp7 limits cranial bone initiation sites and is required for formation of sutures, 160-72, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.