ZFIN Image: Decker et al., 2014, Fig. 6

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Figure Caption

Fig. 6

DFO partially rescues hypomotility of trpm7 mutants. DFO treatment increased spontaneous motility of 5-dpf, trpm7^b508 mutant larvae. Automated analysis of motility was carried out as in Fig. 2. For each experiment, half of a single clutch of larvae from trpm7 heterozygous adults was treated with 50 µM DFO from 2-5 dpf. Motility of control larvae was unaffected by DFO treatment (Student′s t-test, p>0.4). Motility of the trpm7 mutant was significantly increased by treatment with DFO in darkness (Student′s t-test, p<0.05). Each group tested consisted of 23-24 animals. Error bars represent SEM. Asterisks, significantly different values.

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Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 386(2), Decker, A.R., McNeill, M.S., Lambert, A.M., Overton, J.D., Chen, Y.C., Lorca, R.A., Johnson, N.A., Brockerhoff, S.E., Mohapatra, D.P., Macarthur, H., Panula, P., Masino, M.A., Runnels, L.W., and Cornell, R.A., Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern, 428-39, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.