ZFIN Image: Shin et al., 2012, Fig. 5

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Fig. 5

fgf10a signaling negatively regulates liver formation in wnt2bb mutants. (A) Wnt/β-catenin signaling deficient embryos were treated with SU5402 (1 µM) from 26 hpf onward, and examined at 5 dpf. The liver (arrow) formed in SU5402-treated embryos despite severe morphological defects in the head and trunk. Arrowheads point to the endocrine pancreas. (B) The liver (arrow) also formed in fgf10a^-/-; Wnt/β-catenin signaling deficient embryos. Dorsal views, anterior up. Scale bars, 100 µm. (C) The time-window critical for Fgf function in liver formation was delineated by treating Wnt/β-catenin signaling deficient embryos with SU5402 at multiple time points and for different duration (black bars); recovery indicates the percentage of embryos showing a liver at 5 dpf (n = 9-23 for each treatment).

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Acknowledgments

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Reprinted from Mechanisms of Development, 128(11-12), Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y., Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver, 525-535, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.