ZFIN Image: Don et al., 2016, Fig. 1

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Figure Caption

Fig. 1

The pelvic finless critical region maps to a region on chromosome 15 containing three SNPs in tbx4. (A) Low and intermediate resolution mapping reveals that the pelvic finless critical region lies between 54.1 and 63.7cM on chromosome 15. (B) Region-specific, targeted-enrichment next generation sequencing filtering process revealed three SNPs in tbx4. (C) The three SNPs in exon 3 of tbx4 of pelvic finless zebrafish are predicted to cause two amino acid substitutions (A78V and G79A). (D) Schematic diagram of the conservation of vertebrate TBX4 nuclear localization signal (NLS). The NLS is located within the highly conserved T-box domain of the protein. The sequence of the TBX4 NLS is perfectly conserved amongst vertebrates with hindlimbs or pelvic fins, pelvic finless zebrafish exhibit variations in this motif.

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Phenotype details

Acknowledgments

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