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Fig. S5
Sustained absence of Insulin protein by insaMO at 72 and 96 hpf. Merged and single channel confocal images of 72 hpf (A-B′′) and of 96 hpf (C-D′′) Tg(ins:CFP-NTR) control (A-A′& C-C′′) and insaMO-injected (B-B′ & D-D′′) islets stained for CFP (β cells, green), insulin (red) and glucagon (white). Insulin protein was undetectable in β cells at both stages.
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Reprinted from Developmental Biology, 409(2), Ye, L., Robertson, M.A., Mastracci, T.L., Anderson, R.M., An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration, 354-69, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.