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Fig. S11
Insulin knockdown disrupts islet structure and α cell development. Confocal projections of control and insaMO-injected islets from Tg(ins:CFP-NTR) embryos immunostained for CFP (β cells, green), Glucagon (red), and DNA (blue) at 54 hpf (A,D), 80 hpf (B,E) and 100 hpf (C,F). Islets in insaMO-injected embryos are dysmorphic with insulin-positive β cells aberrantly surrounding a diminished number of Glucagon-positive α cells.
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Reprinted from Developmental Biology, 409(2), Ye, L., Robertson, M.A., Mastracci, T.L., Anderson, R.M., An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration, 354-69, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.