ZFIN Image: Jensen et al., 2015, Fig. S2

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Figure Caption

Fig. S2

Differential effects of VEGF-Ba and VEGF-Aa on developmental angiogenesis in zebrafish embryos. (A) Confocal micrographs of 72-hpf fli1a:EGFP embryos injected with 0.6 pmol scrambled, Vegfba, and Vegfaa morpholinos. White arrows indicate brain vasculatures. Yellow arrows indicate ISVs. (Scale bar in overview, 500 µm; in brain and periphery, 50 µm.) (B) Quantification of the percentage of embryos with defective ISVs in 72-hpf fli1a:EGFP embryos injected with 0.6 pmol scrambled (Ctrl), Vegfba (Ba), or Vegfaa (Aa) morpholino (n = 7–14 embryos/group). ***P < 0.001. (C) Quantification of brain vessel density of 72-hpf fli1a:EGFP embryos injected with 0.6 pmol scrambled (Ctrl), Vegfba (Ba), and Vegfaa (Aa) morpholinos (n = 8–18 embryos/group). *P < 0.05; ***P < 0.001.

Acknowledgments

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